XXII CONGRESSO SIRC 2019
PROGRAMMA
STRUTTURA DEL CONGRESSO
Il Congresso si articola in 10 Macroaree di ricerca comprendenti specifici simposi:
- FRONTIERE NELLE TERAPIE PER L’IPERTENSIONE POLMONARE
Symposium #1: “Frontiers in the treatment of pulmonary hypertension“ - NUOVE VIE DI SEGNALAZIONE NEL SISTEMA CARDIOVASCOLARE
Symposium #2: “Emerging signaling pathways in the cardiovascular system“ - BIOLOGIA VASCOLARE
Symposium #3: “Vascular biology, angiogenesis and inflammation” - CARDIOPROTEZIONE
Symposium #4: “Joint Symposium with Cost Action on Cardioprotection“ - FRONTIERE NELLA CARDIOPROTEZIONE
Symposium #5: “New directions in cardioprotection: the nutrigenomic approach“ - CUORE E CERVELLO
Symposium #6: “From heart to brain: a back and forth journey” - FRONTIERE NELLA FISIOLOGIA MIOCARDICA
Symposium #7: “Cellular Basis of Myocardial Regeneration: Is it really the Time to Press Reset and Start from Scratch?” - INTERAZIONI CARDIACHE
Symposium #8: “Cardiac interactions with other organs” - DISFUNZIONI CARDIACHE
Symposium #9: “Novel target in cardiac function and dysfunction” - DIAGNOSTICA PER IMMAGINI
Symposium #10: “Translational Cardiovascular Imaging”
INCONTRO SOCI SIRC
Assemblea Plenaria dei Soci SIRC
Venerdì 7 Novembre 2019 alle ore 18.30
Palazzo Sersanti, 1° piano, Piazza Giacomo Matteotti, 8
LA SIRC PREMIA I GIOVANI CARDIOSCIENZIATI
La SIRC premierà giovani ricercatori che presenteranno i loro lavori come comunicazioni orale o poster. In particolare, la SIRC ha previsto uno spazio dedicato a una lettura magistrale nel contesto del programma del Congresso Nazionale per valorizzare l’attività di ricerca inedita più brillante svolta da un giovane cardioscienziato. La presentazione del lavoro di ricerca, selezionato dal Comitato Scientifico del Congresso, sarà introdotto dal Presidente della SIRC presso Palazzo Sersanti. Il vincitore del premio Valsalva verrà selezionato da un’apposita Commissione nominata del Direttivo SIRC in collaborazione con la Fondazione CRImola. Il vincitore terrà una lettura magistrale nel contesto del programma del Congresso Nazionale e riceverà il premio, messo a disposizione dalla Fondazione CRImola, in occasione della Cerimonia prevista nell’ultimo giorno del Congresso Nazionale.
PRESENTAZIONE DEGLI ABSTRACT
Nell’ambito del programma scientifico del Congresso sono previste comunicazioni orali e poster. Almeno uno degli Autori delle comunicazioni accettate (come presentazione orale o poster) deve essere iscritto al Congresso. Qualora tutti gli Autori beneficiassero a vario titolo dell’iscrizione gratuita, è richiesto che almeno uno di essi sottoscriva regolare iscrizione al Congresso. Un autore può comparire, in un numero illimitato di abstract, ma ogni autore pagante non può sottomettere più di tre abstract. Gli abstract selezionati per presentazione saranno pubblicati su supporto informatico DVD ed alcuni potranno rientrare in una selezione di abstract pubblicabili dalla rivista scientifi ca internazionale Vascular Pharmacology.
PRESENTAZIONE ORALE
Ciascuna presentazione selezionata avrà una durata di 10 minuti per l’esposizione e 5 minuti per la discussione.
PRESENTAZIONE POSTER
Ciascun poster selezionato verrà esposto e discusso con i Moderatori presso Palazzo Sersanti.
Call for Abstracts
The Program Committee is welcoming the submission of only original ontributions for oral and poster presentations. On-Line Abstract Submission On-Line Submission on the SIRC website (www.sirc-cardio.it) is the only modality that will be accepted by the Program Committee. Scientific contributions should be submitted according to the topics of the congress. Abstract must be written in English. Abstracts whose English language is of poor quality will be rejected. Please, select the preferred type of presentation (Oral or Poster) and whether or not will participate to the Young Researcher Award. Also, indicate the topic of your work and the session to which the abstract should be inserted in case of acceptance. Accepted Abstracts will be scheduled for the Type of Presentations by the Program & Organizing Committee.
The deadline per la submission is 19th september 2019
The number of Abstracts is not limited. However, each paying author may not submit more than three abstracts. Only Abstracts accompanied by the payment of the registration fee will be considered for
inclusion in the final program and for publication in the proceedings of the Congress that will appear on Vascular Pharmacology (Editor-in-Chief: Raffaele De Caterina).
For abstract preparation, please follow the following format:
Instructions for Authors
1) Abstracts should contain the title; a list of author(s); the institution(s) where the investigation was performed and the text. The Title must be in capital letters. For the Institute/Department, the city should be specified without address, in italics; use the numbers in the case of multiple memberships.
2) Presenting author should be underlined. Please list the authors with initials of the first name in uppercase followed by surname.
3) Text must be divided into 4 sections: Objectives, Materials and Methods, Results, Conclusions.
4) The recommended font is time new roman and font size 12. Kindly, set the language to English.
5) Type the entire abstract single-spaced without margins at the top of sides. Do not include bibliographic citations, tables or figures. Text can be maximum 2700 characters long, including spaces. Use only the acronyms and abbreviations common to the other state in full in the first quote.
6) Add the correct email address and mailing address, including phone, fax number, of the presenting author at the end of the abstract.
Abstract template
TITLE NO LONGER THAN 200 CHARACTERS
Y XXXX1, Z LLLL1, S AAAAAA1, F CCCCCC2, C BBBBB3, U ZZZZZZ3, G AAAAAA4
1Department XXX; 2Department YYYY; 3Department ZZZZ; 4Department TTTTTT; City, State
Objectives: Endothelial progenitor cells (EPCs) xxxx.
Materials and methods: EPCs were isolated from yyyy.
Results: SOCE was activated by zzzzz.
Conclusions: We demonstrate that wwwwww.
Name Last name, corresponding author
e-mail: xxxx@yyyy.com
Address and telephone number
Regardless of scientifi c content, Abstracts received after the deadline, or sent in hard copy, and Abstracts not complied according to the instructions will not be accepted.
Notifi cation of Acceptance
Abstract acceptance, day, time and modality of presentation will be communicated directly to the corresponding author of the abstract, as indicated in the abstract submission form, by 19th september 2019. Please, carefully fi ll the e-mail address of the Corresponding
Authors in the abstract submission form).
At least one of the authors for each Oral Communication or Poster accepted is required to be registered to the Congress. The Registered Author is responsible for informing all authors of the status of the Abstract. Posters will be discussed during dedicated sessions. Posters should be posted at the beginning of each session and removed at the end.
Poster Presentation
Four Interactive Poster Sessions will be held during the congress. Authors are requested to hang up their posters from the beginning to the end of the poster section. Poster size should be 120 (height) cm x 80 (width) cm. Poster fi gures need to be made so as to be readable at distance, with clear, visible graphics and large text fonts. Material for hanging up the posters will be provided in the poster area. Authors are requested to be present at their posters during the poster session for which their poster has been scheduled. Prizes will be awarded to the best poster presentations by a Young Investigator.
Abstracts Presented at The Congress Will Be Published On Vascular Pharmacology, An International Journal Indexed In Current Contents/Science Citation Index.
Mercoledì 6 Novembre 2019
13.00-14.00 Registration and Poster display
14.00-14.30 Opening Ceremony & Welcome Messages from the President and the Authorities
14.00-18.00 Poster session I
14.30-15.40 SYMPOSIUM 1:
Frontiers in the treatment of pulmonary hypertension
Chairs: R. Madonna (UNIPI, Italy) – F. Quaini (UNIPR, Italy)
14.30-14.50 Key Lecture:
Carmine Dario Vizza (SAPIENZA UNIVERSITY, Rome, Italy)
“New Frontiers on diagnosis and treatment of Chronic thromboembolic pulmonary hypertension”
14.50-15.10 Key Lecture:
Raffaele De Caterina (UNIPI, Italy)
“Anticoagulant therapy in acute and chronic thromboembolic disease”
15.10-15.25 Oral Presentation
Valentina Mercurio (Federico II University, Naples, Italy)
“Risk assessment in Scleroderma-associated pulmonary arterial hypertension”
15.25-16.15 Coffee Break
15.25-16.15 Poster Discussion
Chairs: T. Angelone, UNICAL, Italy; C. Penna, UNITO, Italy; G. Alloatti, UNIASTISS, Italy
16.15-17.55 SYMPOSIUM 2:
Emerging signaling pathways in the cardiovascular system Chairs: F. Moccia (UNIPV, Italy) – A. Gerbino (UNIBA, Italy)
16.15-16.35 Key Lecture:
Konstantinos Lefkimmiatis (UNIPV & VIMM, Italy)
“Phosphatases in shaping cAMP microdomains: lessons from the cardiovascular
system”
16.35-16.55 Key Lecture:
Alessandra Fiorio Pla (UNITO, Italy)
“Ion channels signature in endothelial cell migration and angiogenesis”
16.55-17.10 Oral Presentation
Lorenzo Santini (Unifi , Florence, Italy)
“Effect of INaL blockers in transgenic mouse models of hypertrophic cardiomyopathy is mutation-specifi c: severe Ca2+ handling
abnormalities as requisite for Ranolazine and GS967 to exert a full effi cacy effect”
17.10-17.25 Oral Presentation
Jessica Gambardella (Federico II University, Naples, Italy)
“Cardiac mitochondrial alterations in a mouse model of Fabry Disease”
17.25-17.40 Oral Presentation
Andrea Gerbino (Uniba, Bari, Italy)
“The functional expression of the Lamin A/C mutant Q517X in HL1 cardiomyocytes causes nuclear and cytoskeleton remodeling with
reduction in spontaneous action potentials frequency”
17.40-17.55 Oral Presentation
Daniela Sorriento (Federico II University, Naples, Italy)
“Role of infl ammation in cardiac damage induced by Doxorubicin”
18.00-18.15 RICORDO DEL PROF. CLAUDIO CALDARERA
introduced by the SIRC President, Prof. Pasquale Pagliaro, and by Prof. Carlo Guarnieri, Unibo
18.15-18.35 PLENARY VALSALVA LECTURE (1)
introduced by the SIRC President, Prof. Pasquale Pagliaro
18.15-18.35 Valsalva Lecture
Alessandro Fantin (Unimi, Milan, Italy)
“Defi ning novel roles for myeloid cells in angiogenesis”
Giovedì 7 Novembre 2019
08.30-13.00 Poster session II
09:00-17:00 Votazioni nuovo direttivo
08.45-10.15 SYMPOSIUM 3: Vascular biology, angiogenesis and inflammation
Chairs: A. Parenti (UNIFI, Italy) – F. Mangiacapra (Campus Biomedico, Italy)
08.45-09.05 Key Lecture:
Paola Rizzo (UNIFE, Italy)
“Heart rate reduction with ivabradine in the early phase of atherosclerosis is protective in the endothelium of ApoE-deficient mice”
09.05-09.25 Key Lecture:
Stefania Loffredo (UNINA, Italy)
“Group V secreted Phospholipase A2 induces the release of proangiogenic and antiangiogenic factors by human neutrophils”
09.25-09.40 Oral Presentations
Francesco Lodola (IIT PoliMi, Milan, Italy)
“Conjugated polymers optically regulate the fate of Endothelial Colony Forming Cells”
09.40-09.55 Oral Presentations
Elisa Di Pasquale (CNR-IRGB Humanitas, Milan Italy)
“Investigation of mechanisms of contractile dysfunctions due to LMNA mutations in a iPSC-based cardiac model of laminopathy”
09.55-10.10 Oral Presentations
Roman Vuerich (ICGEB, Trieste Italy)
“Use of autologous endothelial cells for the treatment of nonhealing wounds”
10.10-10.35 Coffee break
10.10-10.35 Poster Discussion
Chairs: T. Angelone, UNICAL, Italy; C. Penna, UNITO, Italy; G. Alloatti,
UNIASTISS, Italy
10.35-11.00 STATE OF THE ART LECTURE: Cardiac sarcomere mechanics and
energetics in health and disease (What we can learn from HCM mutations) Prof. Corrado POGGESI (UNIFI, Italy)
11.00-12.45 SYMPOSIUM 4: Joint Symposium with Cost Action on Cardioprotection
Chairs: P. Pagliaro (UNITO, Italy) – C.G. Tocchetti (UNINA, Italy)
11.00-11.20 Key Lecture:
Antonio Crisafulli (UNICA, Italy)
“Conditioning by exercise in normal subjects and coronary patients”
11.20-11.45 Key Lecture:
Ioanna Andreadou (National and Kapodistrian University of Athens, Greece)
“Old and new pharmacological approaches in cardioprotection”
11.45-12.15 Key Lecture:
Gerd Heusch (Direktor des Institutes fuer Pathophysiologie, Universitaetsklinikum Essen, Germany) “Chances and challenges in the translation of cardioprotection”
12.15-12.30 Oral Presentation
Carmine Rocca (Unical, Cosenza, Italy)
“A new predictive sensor for the doxorubicin-dependent cardiotoxicity: the paradigm of Chromogranin-A
12.30-12.45 Oral Presentation
Elena Guzzolino (CNR Clinical Physiology, Pisa, Italy)
“Cardiac disease models of zebrafi sh to investigate the basis of SGLT2 inhibitor Cardioprotection”
12.45-14.15 Poster view
13.15 Lunch
14.15-19.00 Poster session III
14.15-15.25 SYMPOSIUM 5: New directions in cardioprotection: the nutrigenomic approach
Chairs: V. Lionetti (SSSA, Italy) – M. C. Cerra (UNICAL, Italy)
14.15-14.35 Key Lecture:
Arrigo Francesco Giuseppe Cicero (UNIBO, Italy)
“From nutrients to nutraceuticals: impact on cardiovascular diseases management”
14.35-14.55 Key Lecture:
Vincenzo Calderone (UNIPI, Italy)
“Pharmacology of sulfur nutraceuticals: potential role of hydrogen sulfide”
14.55-15.10 Oral presentation
Michele Russo (Federico II University, Naples, Italy)
“The novel butyrate derivative phenylalanine-butyramide protects from doxorubicin-induced cardiotoxicity”
15.10-15.25 Oral presentation
Marianna Ranieri (Uniba, Bari, Italy)
“Olive Leaf Extract (OLE) counteracts vasopressin-stimulated Aquaporin-2 expression and trafficking displaying a diuretic action”
15.25-16.40 SYMPOSIUM 6: From heart to brain: a back and forth journey
Chairs: V. Lionetti (SSSA, Italy) – T. Pasqua (UNICAL, Italy)
15.25-15.45 Key Lecture:
Cristina Ottaviani (SAPIENZA UNIVERSITY, Rome, Italy)
“Non-invasive brain stimulation techniques in the study of the reciprocal influences between heart and brain”
15.45-16.05 Key Lecture:
Marco Mongillo (UNIPD, Italy)
“Putting together the clues of the everlasting neuro-cardiac liaison”
16.05-16.20 Oral Presentations
Tania Zaglia (Unipd, Padova, Italy)
“Circulating muscle-derived MIR-2016 links skeletal muscle dysfunction to cardiac autonomic denervation”
16.20-16.35 Oral Presentations
Sharon Negri (Unipv, Pavia, taly)
“Flux-independent NMDA receptors induce Ca2+-dependent nitric oxide release from human brain microvascular endothelial cells”
16.40-17.00 COFFEE BREAK
16.40-17.00 Poster Discussion
Chairs: A. Ghigo, UNITO, Italy; A. Parenti, UNIFI, Italy
17.00-18.30 SYMPOSIUM 7: Cellular Basis of Myocardial Regeneration: Is it really the Time to Press Reset and Start from Scratch?
Chairs: S. Bollini (UNIGE, Italy), R. Madonna (UNIPI, Italy), T. Pasqua (UNICAL, Italy)
17.00-17.20 Key Lecture:
Daniele Torella (UNICZ, Italy)
“Solid evidence of adult multipotent cardiac stem cells”
17.20-17.40 Key Lecture:
Georgina M. Ellison-Hughes (London Kings College, UK)
“Rejuvenating the aging heart”
17.40-18.00 Key Lecture:
Serena Zacchigna (UNITS & ICGEB, Italy)
“Understanding the low regenerative and angiogenic potential of the adult heart”
18.00-18.15 Oral Presentations
Federica Marzano (Federico II University of Naples, Italy)
“GRK2 downstream Aldosterone and Mineralocorticoid receptor system induces cardiac insulin-resistance and β-adrenergic dysfunction”
18.15-18.30 Oral Presentations
Edoardo Lazzarini (CardioCentro Ticino, Lugano, Switzerland)
“Systemic delivery of cardiac progenitor cell-derived exosomes ameliorate cardiac dysfunction induced by cancer drugs”
18.30-19.45 Meeting of the SIRC Assembly and new nucleus elections
Scrutinio dei Voti
20.45 Social dinner
Venerdì 8 Novembre 2019
09.00-13.00 Poster session IV
09.00-10.10 SYMPOSIUM 8: Cardiac interactions with other organs
Chairs: P. Ameri (UNIGE, Italy) – C.G. Tocchetti (UNINA, Italy)
09.00-09.20 PLENARY VALSALVA LECTURE (2)
Introduced by the SIRC President Prof. Pasquale Pagliaro
Alessandra Ghigo (UNITO, Italy)
“Pi3K: from cardiac to lung therapies”
09.20-09.40 Key Lecture:
Daniela Carnevale (NeuroMed Pozzilli, IS)
“Heart, spleen, brain”
09.40-09.55 Oral Presentations
Yuri D’Alessandra (Centro Cardiologico Monzino, Milan Italy)
“Circadian genes expression in whole blood is associated with different forms of Coronary Artery Disease”
09.55-11.10 SYMPOSIUM 9: Novel target in cardiac function and dysfunction
Chairs: A. Parenti (UNIFI, Italy) – L. Sartiani (UNIFI, Italy)
09.55-10.15 Key Lecture:
Edoardo Mannuci (UNIFI, Italy)
“SGLT2 inhibitors and beyond: targeted research and serendipity”
10.15-10.35 Key Lecture:
Mirko Baruscotti (UNIMI, Italy)
“Unraveling the role of AMPK in the modulation of heart rate”
10.35-10.55 Key Lecture:
Nina Kaludercic (CNR, Padova)
“Monoamine oxidase-dependent endoplasmic reticulummitochondria dysfunction and mast cell degranulation lead to adverse cardiac remodeling in diabetes”
10.55-11.10 Oral Presentations
Ilaria Minnucci (Unich, Chieti, Italy)
“Empagliflozin reduces senescence of cardiac stromal cells in highglucose culture conditions”
11.10-11.40 COFFEE BREAK
10.10-10.40 Poster Discussion
Chairs: S. Bollini, UNIGE, Italy, L. Sartiani, UNIFI, Italy
10.40 -11.10 SYMPOSIUM 10: Translational Cardiovascular Imaging Chairs: V. Lionetti, SSSA, Pisa – G. Iaccarino, UNINA, Italy
10.40-10.55 Key Lecture:
Nicola G. Martini (Fondazione CNR/Regione Toscana G. Monasterio, Pisa, Italy)
“Novel cardiac magnetic resonance biomarkers in preclinical research”
10.55-11.10 Key lecture:
Silvia Cantoni (CHIESI FARMACEUTICI S.p.A., Parma, Italy)
“Echocardiographic evaluation of pharmacological antagonism of endothelin receptors in a rat model of pulmonary arterial hypertension”
11.10-11.45 GUIDO TARONE LECTURE
Chairs: P. Pagliaro (UNITO, Italy) – M. Brancaccio (UNITO, Italy)
Alessandro Bertero (University of Washington, USA)
“Functional dynamics of chromatin topology in human cardiogenesis and disease”
11.45-12.05 YOUNG INVESTIGATOR LECTURE
Vanessa Doria (Unichi, Chieti, Italy)
“Rejuvenated extracellular vescicles from telomerase/myocardin co-expressing mesenchymal cells promote revascularization and tissue repair in murine myocardial infarction”
12.05-12.30 CEREMONY RESEARCHER AWARDS
12.30 Remarks & Take Home Messages
INFORMAZIONI GENERALI
Sede
I lavori si terranno presso il Palazzo Sersanti, 1° piano (Piazza Giacomo Matteotti, 8
– Imola (BO)), sito a 800 mt (10 minuti a piedi) dalla Stazione Ferroviaria di Imola (Piazzale Anselmo Marabini).
Parcheggio
Piazza Giacomo Matteotti è inserita in un’area pedonale e a traffico limitato.
Cerimonia Inaugurale
L’inaugurazione del Congresso avrà luogo mercoledì 06 novembre 2019 alle ore 14.00 presso Palazzo Sersanti (primo piano).
Alla Cerimonia Inaugurale faranno seguito i lavori congressuali come secondo programma.
Segreteria Organizzativa
La Segreteria Organizzativa è a disposizione dei partecipanti presso il Palazzo Sersanti a partire dalle ore 13.00 di mercoledì 6 novembre e per tutta la durata del Congresso.
Sono previsti i seguenti servizi:
- Nuove iscrizioni
- Registrazione pre-iscritti
- Relatori e Moderatori
Segreteria Scientifica
La Segreteria Scientifi ca della SIRC sarà presente presso la sede congressuale per tutta la durata del Congresso.
Segreteria Soci
La Segreteria Soci sarà presente presso la sede congressuale per tutta la durata del Congresso per dare ai Soci la possibilità di regolarizzare la propria posizione sociale e ritirare il coupon per la partecipazione all’Assemblea Plenaria dei Soci SIRC.
Quote di iscrizione (esclusa IVA)
La quota di iscrizione comprende:
- la partecipazione ai lavori scientifi ci del Congresso
- la cartella congressuale
- il DVD con gli Abstract del Congresso
- le colazioni di lavoro a buffet
La partecipazione alla Cena Sociale non è inclusa nella quota di iscrizione e richiede il pagamento di una quota suppletiva pari a 40 euro entro il 31 ottobre 2019.
(Prima del 15 ottobre 2019)
Non Soci SIRC:
120 € (disoccupati**, PhD students e borsisti/assegnisti di ricerca*)
300 € (strutturati/specializzandi)
Soci SIRC:
40 € (disoccupati**, PhD students e borsisti/assegnisti di ricerca*)
90€ (strutturati/specializzandi)
(Dopo il 15 ottobre 2019 o al DESK del Congresso)
Non Soci SIRC:
150 € (disoccupati**, PhD students e borsisti/assegnisti di ricerca*)
350 € (strutturati/specializzandi).
Soci SIRC:
50 € (disoccupati**, PhD students e borsisti/assegnisti di ricerca*)
150€ (strutturati/specializzandi)
Soci: purché siano in regola con il pagamento delle quote associative a partire dal 2014 o a partire dalla quota associativa della loro data di iscrizione, se successiva al 2014.
Quota associativa annuale:
20 € per disoccupati**, PhD student e borsisti/asssegnisti di ricerca*
50 € per strutturati/specializzandi.
(Quote giornaliere)
Non Soci SIRC
100 € (strutturati/specializzandi)
50 € (disoccupati**, PhD students e borsisti/assegnisti di ricerca*)
Partecipazione gratuita (Solo studenti universitari laureandi*).
* È richiesto il Certificato attestante lo stato di Studente, Borsista/Assegnista di ricerca
** È richiesta l’autocertificazione attestante lo stato di Disoccupato Almeno uno degli Autori delle comunicazioni accettate (come presentazione orale o poster) deve essere iscritto al Congresso.
Qualora tutti gli Autori beneficiassero a vario titolo dell’iscrizione gratuita, è richiesto che almeno uno di essi sottoscriva regolare iscrizione al Congresso.
Modalità di pagamento
Il pagamento in euro intestato alla Società Italiana di Ricerche Cardiovascolari può essere effettuato mediante:
- bollettino postale – Conto corrente n: 25038407
- bonifico bancario – IBAN: it17c0760102400000025038407
(Ufficio Postale di Torino – Succursale 6, Corso Racconigi 43, 10139 Torino)
La ricevuta del pagamento dovrà essere spedita al Segretario della SIRC, dott.ssa Teresa Pasqua, al seguente indirizzo: teresa.pasqua@unical.it
L’iscrizione al Congresso può essere anche pagata in contanti al Desk. Per ogni iscrizione verraÌ rilasciata una ricevuta; è necessario quindi che sia indicato il Codice Fiscale.
Cancellazione e Rimborso
Per cancellare una registrazione occorre spedire una e-mail, motivandola, al seguente indirizzo e-mail: segreteriasirc@sirc-cardio.it
- Le richieste di cancellazione ricevute entro il 31 Ottobre 2019 saranno rimborsate al 50%.
- Le richieste di cancellazione ricevute dopo il 31 Ottobre 2019 non saranno
rimborsate.
